产品
编 号：F701663
分子式：C25H16ClF2N3O5S
分子量：543.93
分子式：C25H16ClF2N3O5S
分子量：543.93
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CAS No: 1642112-32-0
产品详情
生物活性：
AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC50s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM.
体内研究：
Animal Model:C57Bl/6 male mice
Dosage:100 mg/kg
Administration:oral
Result:Failed to show a statistically significant effect on scratching behavior.
AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC50s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM.
体内研究：
Animal Model:C57Bl/6 male mice
Dosage:100 mg/kg
Administration:oral
Result:Failed to show a statistically significant effect on scratching behavior.
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