产品
编 号：F701497
分子式：C20H26N6O4S3
分子量：510.65
分子式：C20H26N6O4S3
分子量：510.65
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1638148-50-1
产品详情
生物活性：
DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC50app of 27.8 nM and Kiapp of 9.2 nM. DI-82 has antitumor activity.
体外研究：
DI-82 (compound 12R) has an IC50 of 3.7 nM in CCRF-CEM acute lymphoblastic leukemia cells. DI-82 (1 μM) has a NADPH-dependent CLint of 22.7 μL/min?mg and a NADPH-dependent T1/2 of 102 mins in a standard microsomal liver clearance assay. DI-82 (200?μM) completely blunts the ability of decitabine to bind human thymidylate synthase (TS).
DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC50app of 27.8 nM and Kiapp of 9.2 nM. DI-82 has antitumor activity.
体外研究：
DI-82 (compound 12R) has an IC50 of 3.7 nM in CCRF-CEM acute lymphoblastic leukemia cells. DI-82 (1 μM) has a NADPH-dependent CLint of 22.7 μL/min?mg and a NADPH-dependent T1/2 of 102 mins in a standard microsomal liver clearance assay. DI-82 (200?μM) completely blunts the ability of decitabine to bind human thymidylate synthase (TS).
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