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编 号：F699905
分子式：C17H19F3N6O.C4H6O6.4H2O
分子量：602.52
分子式：C17H19F3N6O.C4H6O6.4H2O
分子量：602.52
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CAS No: 1607431-21-9
产品详情
生物活性：
Upadacitinib (ABT-494) tartrate tetrahydrate is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib tartrate tetrahydrate displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib tartrate tetrahydrate can be used for several autoimmune disorders research.
体内研究：
Upadacitinib (0.1-10 mg/kg; oral gavage; twice a day for 10 days) tartrate tetrahydrate demonstrates efficacy in rat arthritis models.Animal Model:Female Lewis rats (Rat adjuvant-induced arthritis model)
Dosage:0.1, 0.3, 1, 3, 10 mg/kg
Administration:Oral gavage; twice a day for 10 days
Result:Inhibited disease pathology in rat adjuvant induced arthritis.
体外研究：
In biochemical assays, Upadacitinib tartrate tetrahydrate is 74-fold more selective for JAK-1 than for JAK-2 (which is involved in erythropoiesis) and 58-fold more selective for JAK-1 than for JAK-3 (which is involved in immunosurveillance).
Upadacitinib (ABT-494) tartrate tetrahydrate is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib tartrate tetrahydrate displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib tartrate tetrahydrate can be used for several autoimmune disorders research.
体内研究：
Upadacitinib (0.1-10 mg/kg; oral gavage; twice a day for 10 days) tartrate tetrahydrate demonstrates efficacy in rat arthritis models.Animal Model:Female Lewis rats (Rat adjuvant-induced arthritis model)
Dosage:0.1, 0.3, 1, 3, 10 mg/kg
Administration:Oral gavage; twice a day for 10 days
Result:Inhibited disease pathology in rat adjuvant induced arthritis.
体外研究：
In biochemical assays, Upadacitinib tartrate tetrahydrate is 74-fold more selective for JAK-1 than for JAK-2 (which is involved in erythropoiesis) and 58-fold more selective for JAK-1 than for JAK-3 (which is involved in immunosurveillance).
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