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CAS No: 156679-34-4
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生物活性：
Lenercept (Ro 45-2081) is a recombinant fusion protein that consists of the soluble TNF-receptor (p55) linked to the Fc portion of human IgG1.
体内研究：
Lenercept (Ro 45-2081) 抑制 Sephadex 诱导的大鼠肺损伤。Lenercept (TNFR-IgG; 0.8-20 μg/mouse; i.v.; once) 当内毒素激发之前或之后不久给药时，可以预防或显著延迟内毒素诱导的小鼠致死率。Animal Model:Male Sprague-Dawley rats
Dosage:1 and 3 mg/kg
Administration:Intraperitoneal injection, 1 h before administration of Sephadex for the 24 h study or 1 h before and at 24 and 48 h after Sephadex for the 72 h study
Result:Inhibited the neutrophilia at 24 h after Sephadex. At 72 h after Sephadex, significantly reduced the neutrophil influx into bronchoalveolar lavage fluid (BALF) but had no inhibitory effect on eosinophil number.
Animal Model:6- to 8-week-old female BALB/c mice, septic shock model
Dosage:0.8, 4 or 20 μg/mouse
Administration:IV, single dose
Result:Injection 0.5 h prior to Salmonella abortus-derived endotoxin (LD100 dose) administration prevented lethality at a dose of 20 μg per mouse and provided partial protection at lower doses. Injection of 10 μg per mouse provided significant protection 0.5 h before, 0.5 h after, or 1 h after endotoxin injection but little protection 2 h after endotoxin injection.
体外研究：
Lenercept (TNFR-IgG) 在放线菌素 D (HY-17559) 处理的小鼠 L-M 细胞中阻断 TNF-α 和 TNF-β 的细胞溶解作用，IC50 分别为 0.5 μg/mL 和 1.5 μg/mL。
Lenercept (Ro 45-2081) is a recombinant fusion protein that consists of the soluble TNF-receptor (p55) linked to the Fc portion of human IgG1.
体内研究：
Lenercept (Ro 45-2081) 抑制 Sephadex 诱导的大鼠肺损伤。Lenercept (TNFR-IgG; 0.8-20 μg/mouse; i.v.; once) 当内毒素激发之前或之后不久给药时，可以预防或显著延迟内毒素诱导的小鼠致死率。Animal Model:Male Sprague-Dawley rats
Dosage:1 and 3 mg/kg
Administration:Intraperitoneal injection, 1 h before administration of Sephadex for the 24 h study or 1 h before and at 24 and 48 h after Sephadex for the 72 h study
Result:Inhibited the neutrophilia at 24 h after Sephadex. At 72 h after Sephadex, significantly reduced the neutrophil influx into bronchoalveolar lavage fluid (BALF) but had no inhibitory effect on eosinophil number.
Animal Model:6- to 8-week-old female BALB/c mice, septic shock model
Dosage:0.8, 4 or 20 μg/mouse
Administration:IV, single dose
Result:Injection 0.5 h prior to Salmonella abortus-derived endotoxin (LD100 dose) administration prevented lethality at a dose of 20 μg per mouse and provided partial protection at lower doses. Injection of 10 μg per mouse provided significant protection 0.5 h before, 0.5 h after, or 1 h after endotoxin injection but little protection 2 h after endotoxin injection.
体外研究：
Lenercept (TNFR-IgG) 在放线菌素 D (HY-17559) 处理的小鼠 L-M 细胞中阻断 TNF-α 和 TNF-β 的细胞溶解作用，IC50 分别为 0.5 μg/mL 和 1.5 μg/mL。
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