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编 号：F696400
分子式：C119H194N28O33S
分子量：2577.05
分子式：C119H194N28O33S
分子量：2577.05
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CAS No: 155178-13-5
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生物活性：
Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway.
体外研究：
Amyloid 17-42 (20 μM; 48 h) leads to apoptosis in SH-SY5Y and IMR-32 cells. Amyloid 17-42 (20 μM; 48 h, 72 h) activates caspase-8 and caspase-3, induced poly(ADP-ribose) polymerase cleavage. Amyloid 17-42 (20 μM) moderately activates c-Jun N-terminal kinase (JNK).Amyloid 17-42 induces neuronal apoptosis via a Fas-like/caspase-8 activation pathway.
Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway.
体外研究：
Amyloid 17-42 (20 μM; 48 h) leads to apoptosis in SH-SY5Y and IMR-32 cells. Amyloid 17-42 (20 μM; 48 h, 72 h) activates caspase-8 and caspase-3, induced poly(ADP-ribose) polymerase cleavage. Amyloid 17-42 (20 μM) moderately activates c-Jun N-terminal kinase (JNK).Amyloid 17-42 induces neuronal apoptosis via a Fas-like/caspase-8 activation pathway.
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