产品
编 号：F696357
分子式：C21H24N4O2
分子量：364.44
分子式：C21H24N4O2
分子量：364.44
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CAS No: 1551403-51-0
产品详情
生物活性：
BMT-090605 is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 can be used for the research of neuropathic pain.
体内研究：
BMT-090605 (intrathecal; 0.3-3 μg/rat) causes antinociception by inhibiting AAK1 in the spinal cord.Animal Model:Male Sprague-Dawley rats (chronic constriction injury (CCI) model)
Dosage:0.3-3 μg/rat
Administration:Intrathecal
Result:Caused a dose-dependent reduction in thermal hyperalgesia.
体外研究：
BMT-090605 shows AAK1inhibitory activity with an IC50 of 0.63 nM.BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively.
BMT-090605 is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 can be used for the research of neuropathic pain.
体内研究：
BMT-090605 (intrathecal; 0.3-3 μg/rat) causes antinociception by inhibiting AAK1 in the spinal cord.Animal Model:Male Sprague-Dawley rats (chronic constriction injury (CCI) model)
Dosage:0.3-3 μg/rat
Administration:Intrathecal
Result:Caused a dose-dependent reduction in thermal hyperalgesia.
体外研究：
BMT-090605 shows AAK1inhibitory activity with an IC50 of 0.63 nM.BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively.
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