产品
编 号：F694816
分子式：C25H18F2N4O3
分子量：460.43
分子式：C25H18F2N4O3
分子量：460.43
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1528546-94-2
产品详情
生物活性：
BPI-9016M is a potent, orally active, and?selective dual c-Met and AXL tyrosine kinases inhibitor. BPI-9016M suppresses tumor cell growth, migration and invasion of lung adenocarcinoma.
体内研究：
BPI-9016M (60 mg/kg; p.o.; daily for 16 or 12 days) dramatically restrains tumor growth in PDX xenografts in NOD/SCID mice.Animal Model:NOD/SCID mice
Dosage:60 mg/kg
Administration:p.o.; daily for 16 or 12 days
Result:Dramatically restrained tumor growth in PDX xenografts in NOD/SCID mice.
体外研究：
BPI-9016M (6.3-25 μM; 2 weeks) inhibited cell proliferation. BPI-9016M (12.5-50 μM; 24 hpurs) induces accumulation of more tumor cells in the G1 phase.BPI-9016M (3.1-50 μM) reduces expression of c-Met, p-c-Met, p-AKT and p-ERK in the H1299 and A549 cells in a dose-dependent manner.The IC50 of BPI-9016M in several lung adenocarcinoma cell lines (?A549, H1299, H1650, H1975, HCC827, and PC-9 cells) as well as in primary lung adenocarcinoma cells are ranged from 5.3 μM to 27.1 μM.
BPI-9016M is a potent, orally active, and?selective dual c-Met and AXL tyrosine kinases inhibitor. BPI-9016M suppresses tumor cell growth, migration and invasion of lung adenocarcinoma.
体内研究：
BPI-9016M (60 mg/kg; p.o.; daily for 16 or 12 days) dramatically restrains tumor growth in PDX xenografts in NOD/SCID mice.Animal Model:NOD/SCID mice
Dosage:60 mg/kg
Administration:p.o.; daily for 16 or 12 days
Result:Dramatically restrained tumor growth in PDX xenografts in NOD/SCID mice.
体外研究：
BPI-9016M (6.3-25 μM; 2 weeks) inhibited cell proliferation. BPI-9016M (12.5-50 μM; 24 hpurs) induces accumulation of more tumor cells in the G1 phase.BPI-9016M (3.1-50 μM) reduces expression of c-Met, p-c-Met, p-AKT and p-ERK in the H1299 and A549 cells in a dose-dependent manner.The IC50 of BPI-9016M in several lung adenocarcinoma cell lines (?A549, H1299, H1650, H1975, HCC827, and PC-9 cells) as well as in primary lung adenocarcinoma cells are ranged from 5.3 μM to 27.1 μM.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备