产品
编 号：F688540
分子式：C29H46N8O5
分子量：586.73
分子式：C29H46N8O5
分子量：586.73
产品类型
规格
价格
是否有货
结构图
CAS No: 1442106-10-6
产品详情
生物活性：
MM-401 is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 μM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia.
体外研究：
MM-401 maintains high binding affinity to WDR5 with a Ki value of MM-401 相关抗体:Apoptosis AnalysisCell Line:Murine MLL-AF9 and Hoxa9/Meis1 cells
Concentration:0, 20, 40 μM
Incubation Time:48 h
Result:Specifically induced apoptosis of MLL-AF9 cells.
Cell Cycle AnalysisCell Line:Murine MLL-AF9 and Hoxa9/Meis1 cells
Concentration:10, 20, 40 μM
Incubation Time:48 h
Result:Induced prominent G1/S arrest in MLL-AF9 cells in a concentration dependent manner.
RT-PCRCell Line:MLL-AF9 cells
Concentration:20 μM
Incubation Time:48 h
Result:Significantly decreased H3K4me, expression of 5 Hox A genes, especially Hoxa9 and Hoxa10.
MM-401 is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 μM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia.
体外研究：
MM-401 maintains high binding affinity to WDR5 with a Ki value of MM-401 相关抗体:Apoptosis AnalysisCell Line:Murine MLL-AF9 and Hoxa9/Meis1 cells
Concentration:0, 20, 40 μM
Incubation Time:48 h
Result:Specifically induced apoptosis of MLL-AF9 cells.
Cell Cycle AnalysisCell Line:Murine MLL-AF9 and Hoxa9/Meis1 cells
Concentration:10, 20, 40 μM
Incubation Time:48 h
Result:Induced prominent G1/S arrest in MLL-AF9 cells in a concentration dependent manner.
RT-PCRCell Line:MLL-AF9 cells
Concentration:20 μM
Incubation Time:48 h
Result:Significantly decreased H3K4me, expression of 5 Hox A genes, especially Hoxa9 and Hoxa10.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备