产品
编 号：F684473
分子式：C19H22ClNO5
分子量：379.83
分子式：C19H22ClNO5
分子量：379.83
产品类型
规格
价格
是否有货
结构图
CAS No: 137275-80-0
产品详情
生物活性：
Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder.
体内研究：
Osemozotan hydrochloride (1 mg/kg; i.p.; 20 min after picrotoxin treatment) ameliorates picrotoxin-induced decrease in female preference with the combination of (+)-SKF-10,047.Osemozotan hydrochloride (1 mg/kg; i.p.; once) decreases the number of c-Fos-positive cells caused by MAMP.Animal Model:Female CD-1 mice with picrotoxin-induced decrease in female preference
Dosage:1 mg/kg
Administration:Intraperitoneal injection; 1 mg/kg; 20 min after picrotoxin treatment
Result:Ameliorated the picrotoxin-induced decrease in the female preference by co-administration WITH (+)-SKF-10,047 (5 mg/kg). Showed no effect on the picrotoxin-induced decrease in the female preference when treated alone.
Animal Model:ICR mice with MAMP injection
Dosage:1 mg/kg
Administration:Intraperitoneal injection; 1 mg/kg; once
Result:Significantly decreased the number of c-Fos-positive cells induced by MAMP in the medial prefrontal cortex and striatum, but did not change the number of c-Fos-positive cells.
Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder.
体内研究：
Osemozotan hydrochloride (1 mg/kg; i.p.; 20 min after picrotoxin treatment) ameliorates picrotoxin-induced decrease in female preference with the combination of (+)-SKF-10,047.Osemozotan hydrochloride (1 mg/kg; i.p.; once) decreases the number of c-Fos-positive cells caused by MAMP.Animal Model:Female CD-1 mice with picrotoxin-induced decrease in female preference
Dosage:1 mg/kg
Administration:Intraperitoneal injection; 1 mg/kg; 20 min after picrotoxin treatment
Result:Ameliorated the picrotoxin-induced decrease in the female preference by co-administration WITH (+)-SKF-10,047 (5 mg/kg). Showed no effect on the picrotoxin-induced decrease in the female preference when treated alone.
Animal Model:ICR mice with MAMP injection
Dosage:1 mg/kg
Administration:Intraperitoneal injection; 1 mg/kg; once
Result:Significantly decreased the number of c-Fos-positive cells induced by MAMP in the medial prefrontal cortex and striatum, but did not change the number of c-Fos-positive cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备