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编 号：F683768
分子式：C25H38FN5O4
分子量：491.6
分子式：C25H38FN5O4
分子量：491.6
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CAS No: 1361200-34-1
产品详情
生物活性：
BN201 promotes neuronal differentiation, the differentiation of precursor cells to mature oligodendrocytes (EC50 of 6.3 μM) in vitro, and the myelination of new axons (EC50 of 16.6 μM). BN201 is able to cross the blood-brain barrier by active transport and activate pathways (IGF-1 pathway) associated with the response to stress and neuron survival. BN201 has potently neuroprotective effects.
体内研究：
BN201 (12.5-150 mg/kg; intraperitoneal injection; daily; for 30 days; female C57BL/6 mice) treatment displays less axonal loss and neuron loss in both the spinal cord and in the optic nerve than the animals that received placebo.Animal Model:Female C57BL/6 mice (8-12 weeks old) by immunization with MOG35-55 (experimental autoimmune encephalitis , EAE)
Dosage:12.5 mg/kg, 25 mg/kg, 50 mg/kg, 100 mg/kg, 150 mg/kg
Administration:Intraperitoneal injection; daily; for 30 days
Result:Displayed less axonal loss and neuron loss in both the spinal cord and in the optic nerve than the animals that received placebo.
体外研究：
BN201 (10 μM; 0.5-4 hours; Hela cells) treatment induces the phosphorylation of NDGR1 in Hela cells in a time-dependent manner.BN201 promotes the survival of cultured neural cells when subjected to oxidative stress or when deprived of trophic factors.
BN201 promotes neuronal differentiation, the differentiation of precursor cells to mature oligodendrocytes (EC50 of 6.3 μM) in vitro, and the myelination of new axons (EC50 of 16.6 μM). BN201 is able to cross the blood-brain barrier by active transport and activate pathways (IGF-1 pathway) associated with the response to stress and neuron survival. BN201 has potently neuroprotective effects.
体内研究：
BN201 (12.5-150 mg/kg; intraperitoneal injection; daily; for 30 days; female C57BL/6 mice) treatment displays less axonal loss and neuron loss in both the spinal cord and in the optic nerve than the animals that received placebo.Animal Model:Female C57BL/6 mice (8-12 weeks old) by immunization with MOG35-55 (experimental autoimmune encephalitis , EAE)
Dosage:12.5 mg/kg, 25 mg/kg, 50 mg/kg, 100 mg/kg, 150 mg/kg
Administration:Intraperitoneal injection; daily; for 30 days
Result:Displayed less axonal loss and neuron loss in both the spinal cord and in the optic nerve than the animals that received placebo.
体外研究：
BN201 (10 μM; 0.5-4 hours; Hela cells) treatment induces the phosphorylation of NDGR1 in Hela cells in a time-dependent manner.BN201 promotes the survival of cultured neural cells when subjected to oxidative stress or when deprived of trophic factors.
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