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编 号:F683126
分子式:C38H37ClN5O7PS2
分子量:806.29
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生物活性:
DC44SMe, a phosphate proagent of cytotoxic DNA alkylator DC44, can be used in the synthesis of antibody-drug conjugate (ADC). DC44SMe exhibits IC50s of 2.0 nM, 2.8 nM, and 1.9 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC44SMe can be used for the targeted treatment of cancer.

体外研究:
The phosphate prodrug may be a suitable choice for ADCs of effector molecules that do not possess sufficient water solubility or stability.
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