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编 号：F677050
分子式：C16H13ClN6
分子量：324.77
分子式：C16H13ClN6
分子量：324.77
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CAS No: 129731-10-8
产品详情
生物活性：
Vorozole is a potent and selective, orally active non-steroidal aromatase inhibitor. Vorozole shows antitumor activity in vivo. Vorozole has the potential for the research of mammary cancer.
体内研究：
Vorozole (0.8-1.25 mg/kg; Gavage; daily for 77 dayss) shows antitumor effect and increase the release of serum insulin-like growth factor (IGF)-1 and serum testosterone levels.Vorozole (p.o.; 5 days) dose-dependently reduced uterus weight and completely inhibited tumor aromatase in ovariectomized nude mice.Animal Model:Female Sprague-Dawley rats
Dosage:0.08, 0.16, 0.31, 0.63 or 1.25 mg/kg
Administration:Gavage; daily (starting at 43 days of age) for 77 days; given a single i.v. dose of methylnitrosourea (MNU) (50 mg/kg body wt) after 7 days
Result:Caused a dose-dependent increase in body weight gain and decrease in cancer incidence, increased the insulin-like growth factor (IGF)-1, serum testosterone levels.
体外研究：
Vorozole inhibits aromatase activity with an IC50s of 1.4 nM inFSH-stimulated rat granulosa cells.
Vorozole is a potent and selective, orally active non-steroidal aromatase inhibitor. Vorozole shows antitumor activity in vivo. Vorozole has the potential for the research of mammary cancer.
体内研究：
Vorozole (0.8-1.25 mg/kg; Gavage; daily for 77 dayss) shows antitumor effect and increase the release of serum insulin-like growth factor (IGF)-1 and serum testosterone levels.Vorozole (p.o.; 5 days) dose-dependently reduced uterus weight and completely inhibited tumor aromatase in ovariectomized nude mice.Animal Model:Female Sprague-Dawley rats
Dosage:0.08, 0.16, 0.31, 0.63 or 1.25 mg/kg
Administration:Gavage; daily (starting at 43 days of age) for 77 days; given a single i.v. dose of methylnitrosourea (MNU) (50 mg/kg body wt) after 7 days
Result:Caused a dose-dependent increase in body weight gain and decrease in cancer incidence, increased the insulin-like growth factor (IGF)-1, serum testosterone levels.
体外研究：
Vorozole inhibits aromatase activity with an IC50s of 1.4 nM inFSH-stimulated rat granulosa cells.
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