产品
编 号：F671094
分子式：C155H259N57O40
分子量：3561.07
分子式：C155H259N57O40
分子量：3561.07
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1220751-16-5
产品详情
生物活性：
TAT-DEF-Elk-1 (TDE) is a cell-penetrating peptide inhibitor of?Elk-1,?mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 activation. TAT-DEF-Elk-1 is a useful tool to analyze the role of Elk-1 in this process during the development of neuronal plasticity.
体内研究：
TAT-DEF-Elk-1 (intraperitoneal?injection; 1mg/kg; daily; 14 days) reflects antidepressant efficacy in mice, it decreases immobility similar to the reference antidepressants fluoxetine and desipramine (DMI).Animal Model:C57Bl6 mice (3-6 months old males) are subjected to social defeat stress
Dosage:1mg/kg;
Administration:Intraperitoneal?injection; daily; 14 days
Result:Reversed social-defeat induced decrease of hippocampal Bdnf expression by repeated TDE administration.
体外研究：
Elk-1 phosphorylation on Ser383/389 has a dual function and triggers both Elk-1 nuclear translocation and SRE-dependent gene expression.TAT-DEF-Elk-1 (5-10 μM; 1 hour) specifically inhibits glutamate-induced elk-1 activation and does not interfer with ERK, MSK-1, or CREB phosphorylation.TAT-DEF-Elk-1 (5 μM; 2 hour) treatment shows a significant inhibition of c-Fos, Zif268 and JunB, but has no effects on c-Jun expression.
TAT-DEF-Elk-1 (TDE) is a cell-penetrating peptide inhibitor of?Elk-1,?mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 activation. TAT-DEF-Elk-1 is a useful tool to analyze the role of Elk-1 in this process during the development of neuronal plasticity.
体内研究：
TAT-DEF-Elk-1 (intraperitoneal?injection; 1mg/kg; daily; 14 days) reflects antidepressant efficacy in mice, it decreases immobility similar to the reference antidepressants fluoxetine and desipramine (DMI).Animal Model:C57Bl6 mice (3-6 months old males) are subjected to social defeat stress
Dosage:1mg/kg;
Administration:Intraperitoneal?injection; daily; 14 days
Result:Reversed social-defeat induced decrease of hippocampal Bdnf expression by repeated TDE administration.
体外研究：
Elk-1 phosphorylation on Ser383/389 has a dual function and triggers both Elk-1 nuclear translocation and SRE-dependent gene expression.TAT-DEF-Elk-1 (5-10 μM; 1 hour) specifically inhibits glutamate-induced elk-1 activation and does not interfer with ERK, MSK-1, or CREB phosphorylation.TAT-DEF-Elk-1 (5 μM; 2 hour) treatment shows a significant inhibition of c-Fos, Zif268 and JunB, but has no effects on c-Jun expression.
产品资料
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