产品
编 号：F664032
分子式：C27H27N9O6
分子量：573.56
分子式：C27H27N9O6
分子量：573.56
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是否有货
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CAS No: 113857-87-7
产品详情
生物活性：
Talotrexin (PT523), an analog of Aminopterin (HY-14518), is a nonpolyglutamatable classic antifolate. Talotrexin is a RFC (reduced folate carrier) specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitumor activity by targeting DHFR to inhibit tumor growth.
体内研究：
Talotrexin (0-35 mg/kg，静脉注射，每周一次，持续 4 周) 单独或与Paclitaxel (HY-B0015, 7.5 mg/kg) 联合使用可抑制小鼠 A549 肿瘤的生长。Animal Model:NSCLC xenografts in athymic female nude mice (6-8 weeks)
Dosage:15, 25, and 35 mg/kg, combined with Paclitaxel (HY-B0015, 7.5 mg/kg)
Administration:IV injection, once weekly for 4 weeks
Result:Inhibited A549 tumor growth.
体外研究：
Talotrexin 未显示出显著的 PCFT 或 FRα 抑制活性。Talotrexin (1-1000 nM) 可抑制 R1-11/Tet-on-RFC HeLa 细胞的增殖。
Talotrexin (PT523), an analog of Aminopterin (HY-14518), is a nonpolyglutamatable classic antifolate. Talotrexin is a RFC (reduced folate carrier) specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitumor activity by targeting DHFR to inhibit tumor growth.
体内研究：
Talotrexin (0-35 mg/kg，静脉注射，每周一次，持续 4 周) 单独或与Paclitaxel (HY-B0015, 7.5 mg/kg) 联合使用可抑制小鼠 A549 肿瘤的生长。Animal Model:NSCLC xenografts in athymic female nude mice (6-8 weeks)
Dosage:15, 25, and 35 mg/kg, combined with Paclitaxel (HY-B0015, 7.5 mg/kg)
Administration:IV injection, once weekly for 4 weeks
Result:Inhibited A549 tumor growth.
体外研究：
Talotrexin 未显示出显著的 PCFT 或 FRα 抑制活性。Talotrexin (1-1000 nM) 可抑制 R1-11/Tet-on-RFC HeLa 细胞的增殖。
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