产品
编 号：F658100
分子式：C22H26FN3O2S
分子量：415.52
分子式：C22H26FN3O2S
分子量：415.52
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规格
价格
是否有货
5mg
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询价
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CAS No: 104383-17-7
产品详情
生物活性：
Sabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties. Sabeluzole protects rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity via preventing tau expression. Sabeluzole enhances memory in rats, and prevents the amnesic effect of Chlordiazepoxide. Sabeluzole can be used fro research of Alzheimer's disease.
体内研究：
Sabeluzole（5 mg/kg，25 mg/kg；sc；两次给药，间隔 72 小时）在 20 mg/kg Chlordiazepoxide 诱导的习惯性遗忘症雄性大鼠中表现出阳性和记忆增强特性。Animal Model:Adult albino male rats (270-330 g) induced by Chlordiazepoxide
Dosage:5 mg/kg, 25 mg/kg
Administration:SC; 0.5 ml/kg; twice dose with 72 h interval; 1 h before 20 mg/kg Chlordiazepoxide
Result:Showed the positive effects on several learning and memory tasks in rats.Did not influence locomotor and rearing activity of animals during the acquisition session.
体外研究：
Sabeluzole（50 nM、100 nM；细胞损伤前 20 分钟）在小脑颗粒细胞原代培养物中对谷氨酸 (50 μM) 介导的兴奋性毒性具有保护作用。Sabeluzole（50 nM；7 天）抑制谷氨酸诱导的 tau 蛋白水平增加。Sabeluzole（50 nM; 4 d）在人神经母细胞瘤细胞系 SH-SY5Y 中表现出神经保护作用。
Sabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties. Sabeluzole protects rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity via preventing tau expression. Sabeluzole enhances memory in rats, and prevents the amnesic effect of Chlordiazepoxide. Sabeluzole can be used fro research of Alzheimer's disease.
体内研究：
Sabeluzole（5 mg/kg，25 mg/kg；sc；两次给药，间隔 72 小时）在 20 mg/kg Chlordiazepoxide 诱导的习惯性遗忘症雄性大鼠中表现出阳性和记忆增强特性。Animal Model:Adult albino male rats (270-330 g) induced by Chlordiazepoxide
Dosage:5 mg/kg, 25 mg/kg
Administration:SC; 0.5 ml/kg; twice dose with 72 h interval; 1 h before 20 mg/kg Chlordiazepoxide
Result:Showed the positive effects on several learning and memory tasks in rats.Did not influence locomotor and rearing activity of animals during the acquisition session.
体外研究：
Sabeluzole（50 nM、100 nM；细胞损伤前 20 分钟）在小脑颗粒细胞原代培养物中对谷氨酸 (50 μM) 介导的兴奋性毒性具有保护作用。Sabeluzole（50 nM；7 天）抑制谷氨酸诱导的 tau 蛋白水平增加。Sabeluzole（50 nM; 4 d）在人神经母细胞瘤细胞系 SH-SY5Y 中表现出神经保护作用。
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