产品
编 号:F656542
分子式:C35H33F4NO5
分子量:623.63
产品类型
结构图
CAS No: 1027642-43-8
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产品详情
生物活性:
BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect.
体内研究:
BAY 60-2770 (0.1-0.3 mg/Kg; p.o.) attenuates liver fibrosis in two rat models.BAY 60-2770 (1 mg/kg; p.o.; daily from the 10th to the 12th week) results in amelioration of bladder dysfunction in high-fat obese mice.Animal Model:Obese mice
Dosage:1 mg/kg
Administration:p.o.; daily from the 10th to the 12th week
Result:Ameliorates detrusor dysfunction in obese mice.