产品
编 号：F653452
分子式：C21H32O6
分子量：380.48
分子式：C21H32O6
分子量：380.48
产品类型
规格
价格
是否有货
结构图
CAS No: 100227-57-4
产品详情
生物活性：
Rustmicin (Galbonolide A) is a potent antifungal agent. Rustmicin inhibits inositol phosphoceramide synthase. Rustmicin shows antifungal activity.
体内研究：
Rustmicin (0、10、20、40、80 mg/kg；腹腔注射；每天两次，持续 4 天) 在隐球菌病小鼠模型中显示出抗真菌活性。Animal Model:DBA/2N mice (Cryptococcus neoformans MY2061)
Dosage:0, 10, 20, 40, 80 mg/kg
Administration:I.p.; twice daily for 4 days
Result:Showed a dose-dependent reduction in colony-forming units isolated from spleen and brain tissue of mice, with the ED99 value of 29 mg/kg for both tissues.
体外研究：
Rustmicin (0-32 μg/mL; 24-48 h) 显示抗真菌活性，对 Cryptococcus neoformans MY1051, Cryptococcus neoformans MY1146, Cryptococcus neoformans MY2061, Cryptococcus neoformans MY2062, C. parapsilosis (MY1010), C. pseudotropicalis (MY2099), C. krusei (MY549), C. tropicalis (MY1012) 菌株的 MIC 值分别为 0.002, 0.001, 0.0001, 0.0002, 0.015, 0.015, 0.031, 0.031 μg/mL。
Rustmicin (Galbonolide A) is a potent antifungal agent. Rustmicin inhibits inositol phosphoceramide synthase. Rustmicin shows antifungal activity.
体内研究：
Rustmicin (0、10、20、40、80 mg/kg；腹腔注射；每天两次，持续 4 天) 在隐球菌病小鼠模型中显示出抗真菌活性。Animal Model:DBA/2N mice (Cryptococcus neoformans MY2061)
Dosage:0, 10, 20, 40, 80 mg/kg
Administration:I.p.; twice daily for 4 days
Result:Showed a dose-dependent reduction in colony-forming units isolated from spleen and brain tissue of mice, with the ED99 value of 29 mg/kg for both tissues.
体外研究：
Rustmicin (0-32 μg/mL; 24-48 h) 显示抗真菌活性，对 Cryptococcus neoformans MY1051, Cryptococcus neoformans MY1146, Cryptococcus neoformans MY2061, Cryptococcus neoformans MY2062, C. parapsilosis (MY1010), C. pseudotropicalis (MY2099), C. krusei (MY549), C. tropicalis (MY1012) 菌株的 MIC 值分别为 0.002, 0.001, 0.0001, 0.0002, 0.015, 0.015, 0.031, 0.031 μg/mL。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备