产品
编 号：F651556
分子式：C111H156N22O43S2
分子量：2550.68
分子式：C111H156N22O43S2
分子量：2550.68
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规格
价格
是否有货
结构图
CAS No: 1096702-14-5
产品详情
生物活性：
EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor. Small molecule-agent conjugate (SMDC).
体内研究：
EC0489 has a favorable toxicology profile in Rats. EC0489 (2, 3, and 4 μmol/kg) has antitumor activity against mice KB tumor models in a dose-dependent manner.
体外研究：
The affinity of EC0489 toward the folate receptor (FR) is approximately half of that of folic acid (relative affinity 0.50).FR-positive KB cells are highly sensitive to EC0489 with an IC50 of 5 nM.
EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor. Small molecule-agent conjugate (SMDC).
体内研究：
EC0489 has a favorable toxicology profile in Rats. EC0489 (2, 3, and 4 μmol/kg) has antitumor activity against mice KB tumor models in a dose-dependent manner.
体外研究：
The affinity of EC0489 toward the folate receptor (FR) is approximately half of that of folic acid (relative affinity 0.50).FR-positive KB cells are highly sensitive to EC0489 with an IC50 of 5 nM.
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