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编 号:F648377
分子式:C26H30N2O6
分子量:466.53
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生物活性:
MK-7145 is a ROMK inhibitor, with an IC50 of 0.045 μM.

体外研究:
MK-7145 (Compound 12) is screened against other members of the Kir family of channels. It doed not show any significant activity on Kir2.1, Kir2.3, Kir4.1, or Kir7.1 channels when tested at concentrations up to 30 μM. MK-7145 is also selective against other cardiac ion channels such as Cav1.2 and Nav1.5 (IC50>30 μM). In a broad counterscreen panel conducted at Panlabs and including over 150 receptors, enzymes, and ion channels, MK-7145 only exhibits three activities at MK-7145 相关抗体:
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