产品
编 号：F067873
分子式：C24H30ClNO3
分子量：415.95
分子式：C24H30ClNO3
分子量：415.95
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
456
In-stock
100mg
684
In-stock
200mg
1064
In-stock
结构图
CAS No: 120011-70-3
产品详情
生物活性：
Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity.
体内研究：
Donepezil 处理 (3 mg/kg) 显著阻止东莨菪碱诱导的小鼠记忆障碍的进展。 Donepezil Hydrochloride 的药代动力学研究表明，口服处理 (3 和 10 mg/kg) 后，Donepezil Hydrochloride 的平均血浆峰值浓度分别约为 1.2 h 和 1.4 h；绝对生物利用度计算为 3.6%。Animal Model:Male imprinting control region (ICR) mice (6 weeks old)
Dosage:3-10 mg/kg
Administration:Administered orally
Result:Pretreatment with 3–10 mg/kg ameliorated scopolamine-induced memory impairment.
Animal Model:Hairless rats with an average weight of 300 g
Dosage:3 and 10 mg/kg (Pharmacokinetic Analysis)
Administration:Administered orally; and blood (250 μL) was collected through the tail vein
Result:After oral treatment (3 and 10 mg/kg), a maximum concentration (Cmax) was reached after approximately 1.2 ± 0.4 h and 1.4 ± 0.5 h, respectively, and gradually decreased.
体外研究：
Donepezil Hydrochloride 的神经保护机制与增强 Akt 和 GSK-3β 的磷酸化，降低tau和糖原合成酶的磷酸化有关。
Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity.
体内研究：
Donepezil 处理 (3 mg/kg) 显著阻止东莨菪碱诱导的小鼠记忆障碍的进展。 Donepezil Hydrochloride 的药代动力学研究表明，口服处理 (3 和 10 mg/kg) 后，Donepezil Hydrochloride 的平均血浆峰值浓度分别约为 1.2 h 和 1.4 h；绝对生物利用度计算为 3.6%。Animal Model:Male imprinting control region (ICR) mice (6 weeks old)
Dosage:3-10 mg/kg
Administration:Administered orally
Result:Pretreatment with 3–10 mg/kg ameliorated scopolamine-induced memory impairment.
Animal Model:Hairless rats with an average weight of 300 g
Dosage:3 and 10 mg/kg (Pharmacokinetic Analysis)
Administration:Administered orally; and blood (250 μL) was collected through the tail vein
Result:After oral treatment (3 and 10 mg/kg), a maximum concentration (Cmax) was reached after approximately 1.2 ± 0.4 h and 1.4 ± 0.5 h, respectively, and gradually decreased.
体外研究：
Donepezil Hydrochloride 的神经保护机制与增强 Akt 和 GSK-3β 的磷酸化，降低tau和糖原合成酶的磷酸化有关。
产品资料
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