产品
编 号：F645380
分子式：C25H50N10O5
分子量：570.73
分子式：C25H50N10O5
分子量：570.73
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1417302-71-6
产品详情
生物活性：
GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice.
体内研究：
GLP-1(32-36)amide (1 μmol/kg; i.p. once daily for 21 d) protects islet from damage, inhibits weight gain, and relieves symptoms of polydipsia in diabetic mice.GLP-1(32-36)amide (1 μmol/kg; a single i.p.) slightly reduces the mean glucose lever at 30 min after the challenge of glucose in normal mice.GLP-1(32-36)amide (50-70 nmol/kg/d; infusion for 12-16 weeks) prevents the development of diet-induced obesity and hepatic steatosis in high fat-fed mice.Animal Model:Male KM mice (6-8 weeks; 18-22 g) injected with STZ
Dosage:1 μmol/kg
Administration:I.p. once daily for 21 days
Result:Signi?cantly lowered the cumulative values of food and water intake.Lowered fasting glucose.Reduced the level of Hemoglobin A1c (HbA1c).Improved glucose tolerance.Suppressed body weight gain.
体外研究：
GLP-1(32-36)amide (0.1-10 μM; 24 h) retains cell viability and decreases apoptosis against Streptozotocin (STZ; 1 μM) in INS-1 cells.
GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice.
体内研究：
GLP-1(32-36)amide (1 μmol/kg; i.p. once daily for 21 d) protects islet from damage, inhibits weight gain, and relieves symptoms of polydipsia in diabetic mice.GLP-1(32-36)amide (1 μmol/kg; a single i.p.) slightly reduces the mean glucose lever at 30 min after the challenge of glucose in normal mice.GLP-1(32-36)amide (50-70 nmol/kg/d; infusion for 12-16 weeks) prevents the development of diet-induced obesity and hepatic steatosis in high fat-fed mice.Animal Model:Male KM mice (6-8 weeks; 18-22 g) injected with STZ
Dosage:1 μmol/kg
Administration:I.p. once daily for 21 days
Result:Signi?cantly lowered the cumulative values of food and water intake.Lowered fasting glucose.Reduced the level of Hemoglobin A1c (HbA1c).Improved glucose tolerance.Suppressed body weight gain.
体外研究：
GLP-1(32-36)amide (0.1-10 μM; 24 h) retains cell viability and decreases apoptosis against Streptozotocin (STZ; 1 μM) in INS-1 cells.
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