产品
编 号：F067687
分子式：C25H26N8
分子量：438.53
分子式：C25H26N8
分子量：438.53
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CAS No: 1199590-75-4
产品详情
生物活性：
GNE-220 is a potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM.
体外研究：
GNE-220 also inhibits a few other kinases with IC50s of 9nM, 476 nM and 1.1μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM+ retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1+ long focal adhesions (FAs).
GNE-220 is a potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM.
体外研究：
GNE-220 also inhibits a few other kinases with IC50s of 9nM, 476 nM and 1.1μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM+ retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1+ long focal adhesions (FAs).
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