产品
编 号：F007848
分子式：C9H7NO3S
分子量：209.22
分子式：C9H7NO3S
分子量：209.22
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
368
In-stock
5mg
920
In-stock
10mg
1560
In-stock
25mg
3120
In-stock
50mg
5040
In-stock
结构图
CAS No: 101714-41-4
产品详情
生物活性：
BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress.
体内研究：
BiP inducer X administration reduces the insults due to cerebral infarction.A 20?μg portion of BiP inducer X administration reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion.Animal Model:Male adult ddY mice weighing 24-34?g (Japan SLC)
Dosage:20?μg (2?μl)
Administration:Intracerebroventricularly
Result:Significantly increased the level of BiP protein 24?h after administration, confirming that administration of BIX induces BiP protein in vivo.
体外研究：
BiP inducer X (5?μM; 0-12 hours; SK-N-SH cells) increase BiP protein.The induction of BiP by BiP inducer X (BIX) is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway.BiP inducer X (5?μM; 12 hours; pretreatment with SK-N-SH cells) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4.
BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress.
体内研究：
BiP inducer X administration reduces the insults due to cerebral infarction.A 20?μg portion of BiP inducer X administration reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion.Animal Model:Male adult ddY mice weighing 24-34?g (Japan SLC)
Dosage:20?μg (2?μl)
Administration:Intracerebroventricularly
Result:Significantly increased the level of BiP protein 24?h after administration, confirming that administration of BIX induces BiP protein in vivo.
体外研究：
BiP inducer X (5?μM; 0-12 hours; SK-N-SH cells) increase BiP protein.The induction of BiP by BiP inducer X (BIX) is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway.BiP inducer X (5?μM; 12 hours; pretreatment with SK-N-SH cells) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4.
产品资料
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