产品
编 号：F638672
分子式：C27H24IN3O2S
分子量：581.47
分子式：C27H24IN3O2S
分子量：581.47
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规格
价格
是否有货
10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 2410846-16-9
产品详情
生物活性：
SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target.
体外研究：
SIC5-6 (30 μM, 100 μM) 增加 HeLa 细胞中 Caspase-1 活性和 Rad21 裂解。(Rad21：含有与荧光染料 Rh110 (HY-D0817) 结合的 Separase 裂解位点)
SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target.
体外研究：
SIC5-6 (30 μM, 100 μM) 增加 HeLa 细胞中 Caspase-1 活性和 Rad21 裂解。(Rad21：含有与荧光染料 Rh110 (HY-D0817) 结合的 Separase 裂解位点)
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