产品
编 号:F634084
分子式:C19H21ClFN5O4
分子量:437.85
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1mg
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询价
5mg
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生物活性:
Zabofloxacin hydrochloride (DW-224a) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin hydrochloride has excellent activity against gram-positive pathogens including?Steptococcus aureus,?Streptococcus pyogenes?and?S.pneumonia. Zabofloxacin hydrochloride is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP).

体外研究:
Zabofloxacin shows a highly potent in vitro activity against clinical isolates of penicillin-sensitive?S. pneumoniae?(minimum inhibitory concentration, MIC90: 0.03 mg/L) and penicillin-resistant?S. pneumoniae?(MIC90: 0.03 mg/L). Against quinolone-resistant?S. pneumoniae,?zabofloxacin (MIC90: 1 mg/L) is more active than ciprofloxacin, sparfloxacin, and moxifloxacin.
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