产品
编 号：F631346
分子式：C17H17F3N2O3
分子量：354.32
分子式：C17H17F3N2O3
分子量：354.32
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 848057-98-7
产品详情
生物活性：
SPHINX is a selective SRPK1 inhibitor with an IC50 value of 0.58 μM. SPHINX effectively reduces Choroidal Neovascularization (CNV) in vivo. SPHINX can be used for the research of (age-related macular degenaration) AMD.
体内研究：
SPHINX (10 ng; i.o. on laser photocoagulation day 0 and day 7) affects neovascular growth in vivo.SPHINX (25 ng; i.o. on laser photocoagulation day 0 and day 7) affects the CNV area in CNV rats.Animal Model:C57/B6 mice with laser-induced CNV
Dosage:10 ng
Administration:Intraocular injection; 10 ng on laser photocoagulation day 0 and day 7
Result:Significantly reduced neovascular growth compared with saline-injected controls.
Animal Model:Norway Brown rats with laser-induced choroidal neovascularization
Dosage:25 ng (10 ng/uL)
Administration:Intraocular injection; 25 ng (10 ng/uL) on laser photocoagulation day 0 and day 7
Result:Significantly reduced the CNV area compared with saline injected controls.
体外研究：
SPHINX (10 μM; 2 h) affects EGF-induced phosphorylation of SRSF1 and SRSF2.SPHINX (5 μM; 24 h) reduces the expression of VEGF165 relative to GAPDH control either in primary RPE and ARPE-19 cell lines.
SPHINX is a selective SRPK1 inhibitor with an IC50 value of 0.58 μM. SPHINX effectively reduces Choroidal Neovascularization (CNV) in vivo. SPHINX can be used for the research of (age-related macular degenaration) AMD.
体内研究：
SPHINX (10 ng; i.o. on laser photocoagulation day 0 and day 7) affects neovascular growth in vivo.SPHINX (25 ng; i.o. on laser photocoagulation day 0 and day 7) affects the CNV area in CNV rats.Animal Model:C57/B6 mice with laser-induced CNV
Dosage:10 ng
Administration:Intraocular injection; 10 ng on laser photocoagulation day 0 and day 7
Result:Significantly reduced neovascular growth compared with saline-injected controls.
Animal Model:Norway Brown rats with laser-induced choroidal neovascularization
Dosage:25 ng (10 ng/uL)
Administration:Intraocular injection; 25 ng (10 ng/uL) on laser photocoagulation day 0 and day 7
Result:Significantly reduced the CNV area compared with saline injected controls.
体外研究：
SPHINX (10 μM; 2 h) affects EGF-induced phosphorylation of SRSF1 and SRSF2.SPHINX (5 μM; 24 h) reduces the expression of VEGF165 relative to GAPDH control either in primary RPE and ARPE-19 cell lines.
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