产品
编 号：F628159
分子式：C17H21N5
分子量：295.38
分子式：C17H21N5
分子量：295.38
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CAS No: 1027330-97-7
产品详情
生物活性：
A-943931 is a potent and selective histamine H4 receptor (H4R) antagonist with pKi values of 4.6, 3.8 nM for human and rat H4R, respectively. A-943931 shows anti-inflammatory and antinociceptive efficacy.
体内研究：
A-943931 在酵母聚糖诱导的小鼠腹膜炎中表现出抗炎活性，皮下注射和腹腔注射的ED50 值分别为 34, 33 μmol/kg。A-943931 (10, 30, 100 μmol/kg; 腹腔注射) 在大鼠的炎症性疼痛和神经性疼痛模型中表现出镇痛效果。Animal Model:Rats (carrageenan-induced inflammatory pain and spinal nerve ligation model of neuropathic pain)
Dosage:10, 30, 100 μmol/kg
Administration:I.p.
Result:Showed antinociceptive efficacy in an inflammatory pain model in rat at an ED50 value of 72 μmol/kg, ip, and in a neuropathic pain model at an ED50 value of 100 μmol/kg, ip.
A-943931 is a potent and selective histamine H4 receptor (H4R) antagonist with pKi values of 4.6, 3.8 nM for human and rat H4R, respectively. A-943931 shows anti-inflammatory and antinociceptive efficacy.
体内研究：
A-943931 在酵母聚糖诱导的小鼠腹膜炎中表现出抗炎活性，皮下注射和腹腔注射的ED50 值分别为 34, 33 μmol/kg。A-943931 (10, 30, 100 μmol/kg; 腹腔注射) 在大鼠的炎症性疼痛和神经性疼痛模型中表现出镇痛效果。Animal Model:Rats (carrageenan-induced inflammatory pain and spinal nerve ligation model of neuropathic pain)
Dosage:10, 30, 100 μmol/kg
Administration:I.p.
Result:Showed antinociceptive efficacy in an inflammatory pain model in rat at an ED50 value of 72 μmol/kg, ip, and in a neuropathic pain model at an ED50 value of 100 μmol/kg, ip.
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