产品
编 号：F627595
分子式：C17H12INO5
分子量：437.19
分子式：C17H12INO5
分子量：437.19
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 1094048-77-7
产品详情
生物活性：
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells.?I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50?of 1 μM.
体外研究：
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) (0.1-1000 μM；24 小时) 在营养缺乏的培养基中对 PANC-1 细胞具有细胞毒性。 I-OMe-Tyrphostin AG 538 (0-3 μM；1 小时) 阻断 IGF-1R、Akt 和 Erk 的磷酸化。
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells.?I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50?of 1 μM.
体外研究：
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) (0.1-1000 μM；24 小时) 在营养缺乏的培养基中对 PANC-1 细胞具有细胞毒性。 I-OMe-Tyrphostin AG 538 (0-3 μM；1 小时) 阻断 IGF-1R、Akt 和 Erk 的磷酸化。
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