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编 号:F626236
分子式:C20H14Cl2N6O5S
分子量:521.33
产品类型
结构图
CAS No: 1207993-83-6
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生物活性:
Bozepinib is a PKR (RNA-dependent protein kinase) activator and potently inhibits the HER-2 signaling pathway as well as JNK and ERK kinases. Bozepinib induces PKR-mediated apoptosis and synergizes with IFNα to trigger apoptosis, autophagy and senescence. Bozepinib also demonstrates in vivo antitumor and antimetastatic efficacy in xenografted nude mice.