产品
编 号:F625960
分子式:C22H20BrN3O3S
分子量:486.38
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10mM*1mL in DMSO
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1mg
320
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5mg
720
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10mg
1160
In-stock
25mg
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50mg
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100mg
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生物活性:
CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively. Use as a molecular probe.

体外研究:
CID44216842 inhibits GTP binding to both Cdc42 and its mutant in a dose-dependent manner. The inhibition is specific toward Cdc42 with no effects on other GTPases including Rac and Rho in the same family.
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