产品
编 号：F625956
分子式：C15H12N6O2S3
分子量：404.49
分子式：C15H12N6O2S3
分子量：404.49
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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结构图
CAS No: 1222765-97-0
产品详情
生物活性：
NCT-504 is a selective allosteric inhibitor of PIP4Kγ, with an IC50 of 15.8 μM. NCT-504 is potential for the research of Huntington's disease.
体外研究：
NCT-504 dose not impair the intrinsic ATP-hydrolytic activity of PIP4Kγ in the absence of PI5P substrate.NCT-504 does not inhibit PIP4Kbeta and weakly inhibits PIP4Kalpha phosphorylation of PI5P .NCT-504 dose not inhibit PIP4Kbeta or PIP4Kalpha (IC50 between 50 μM and 100 μM) at 50 μM concentration.NCT-504 elevates the levels of PI(3,5)P2, PI3P and PI5P in MEFs.NCT-504 (10 μM; 12 hours) does not affect cell viability in MEFs.NCT-504 (5 μM, 10 μM; 2 hours, 6 hours) elevates both the induction of autophagy as well as the rate of turnover of autophagic cargo.NCT-504 treatment causes a robust increase in the formation of autolysosomes with only a modest elevation in autophagosomes.NCT-504 increases autophagy flux and decreases huntingtin protein in 293A cells.NCT-504 reduces mHtt protein levels in immortalized striatal cells from knock-in HD mice.
NCT-504 is a selective allosteric inhibitor of PIP4Kγ, with an IC50 of 15.8 μM. NCT-504 is potential for the research of Huntington's disease.
体外研究：
NCT-504 dose not impair the intrinsic ATP-hydrolytic activity of PIP4Kγ in the absence of PI5P substrate.NCT-504 does not inhibit PIP4Kbeta and weakly inhibits PIP4Kalpha phosphorylation of PI5P .NCT-504 dose not inhibit PIP4Kbeta or PIP4Kalpha (IC50 between 50 μM and 100 μM) at 50 μM concentration.NCT-504 elevates the levels of PI(3,5)P2, PI3P and PI5P in MEFs.NCT-504 (10 μM; 12 hours) does not affect cell viability in MEFs.NCT-504 (5 μM, 10 μM; 2 hours, 6 hours) elevates both the induction of autophagy as well as the rate of turnover of autophagic cargo.NCT-504 treatment causes a robust increase in the formation of autolysosomes with only a modest elevation in autophagosomes.NCT-504 increases autophagy flux and decreases huntingtin protein in 293A cells.NCT-504 reduces mHtt protein levels in immortalized striatal cells from knock-in HD mice.
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