产品
编 号：F625882
分子式：C22H25NO5S
分子量：415.5
分子式：C22H25NO5S
分子量：415.5
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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结构图
CAS No: 1228439-36-8
产品详情
生物活性：
KCC2 blocker 1 is an orally active and selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate.
体内研究：
KCC2 blocker 1 (compound 13; 1 mg/kg iv and 6 mg/kg po) has a t1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C maxof 457 ng/mL and a AUC of 726 ng?h/mL for male Wistar rats. Animal Model:Male Wistar rats
Dosage:1 mg/kg or 6 mg/kg (Pharmacokinetic Analysis)
Administration:IV (1 mg/kg) and PO (6 mg/kg)
Result:Had a t1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C maxof 457 ng/mL and a AUC of 726 ng?h/mL.
体外研究：
KCC2 blocker 1 (compound 13; 100 μM) inhibits NKCC1 with 35%.
KCC2 blocker 1 is an orally active and selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate.
体内研究：
KCC2 blocker 1 (compound 13; 1 mg/kg iv and 6 mg/kg po) has a t1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C maxof 457 ng/mL and a AUC of 726 ng?h/mL for male Wistar rats. Animal Model:Male Wistar rats
Dosage:1 mg/kg or 6 mg/kg (Pharmacokinetic Analysis)
Administration:IV (1 mg/kg) and PO (6 mg/kg)
Result:Had a t1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C maxof 457 ng/mL and a AUC of 726 ng?h/mL.
体外研究：
KCC2 blocker 1 (compound 13; 100 μM) inhibits NKCC1 with 35%.
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