产品
编 号:F625863
分子式:C20H29ClFN5O2
分子量:425.93
产品类型
结构图
CAS No: 1229603-37-5
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产品详情
生物活性:
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 has an IC50 of 1.2 nM for CCR2 Ca2+ flux .
体外研究:
AZD2423 inhibits MCP-1 induced calcium mobilization and chemotaxis of THP-1 cell line with an IC50 of 4 nM.