产品
编 号：F625717
分子式：C12H14N8O
分子量：286.29
分子式：C12H14N8O
分子量：286.29
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CAS No: 1246018-36-9
产品详情
生物活性：
ST4206 is a potent and orally active adenosine A2A receptor antagonist, with Kis of 12 nM and 197 nM for adenosine A2A receptor and adenosine A1 receptor, respectively. ST4206 has the potential for Parkinson?s disease research.
体内研究：
ST4206 (10, 20, and 40 mg/kg, p.o.) antagonizes haloperidol-induced catalepsy, and increases motor activity in a dose dependent manner in mice.ST4206 (20 and 40 mg/kg) significantly increases the number of contralateral turns induced by l-DOPA in rats. ST4206 is orally active at concentrations of 10, 20, and 40 mg/kg in haloperidol-induced catalepsy in mice.
体外研究：
ST4206 inhibits agonist-induced cAMP accumulation with an IC50 of 990 nM.
ST4206 is a potent and orally active adenosine A2A receptor antagonist, with Kis of 12 nM and 197 nM for adenosine A2A receptor and adenosine A1 receptor, respectively. ST4206 has the potential for Parkinson?s disease research.
体内研究：
ST4206 (10, 20, and 40 mg/kg, p.o.) antagonizes haloperidol-induced catalepsy, and increases motor activity in a dose dependent manner in mice.ST4206 (20 and 40 mg/kg) significantly increases the number of contralateral turns induced by l-DOPA in rats. ST4206 is orally active at concentrations of 10, 20, and 40 mg/kg in haloperidol-induced catalepsy in mice.
体外研究：
ST4206 inhibits agonist-induced cAMP accumulation with an IC50 of 990 nM.
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