产品
编 号：F625577
分子式：C32H44N4O4
分子量：548.72
分子式：C32H44N4O4
分子量：548.72
产品类型
规格
价格
是否有货
结构图
CAS No: 1252806-86-2
产品详情
生物活性：
GB83 is a potent PAR2 antagonist. GB83 reverses neutrophil elastase‐induced synovitis and pain. GB83 blocks the effect of MET-1 supernatant on NG neurons.
体内研究：
GB83 (5 μg; i.p.) reverses neutrophil elastase‐induced synovitis and pain in PAR2 KO mice.Animal Model:8-14 weeks, 20-30 g male C57Bl/6 mice (PAR2 KO mice)
Dosage:5 μg
Administration:I.p.; 3 times at 10?min before and 110 and 230?min after neutrophil elastase administered
Result:Significantly blocked the neutrophil elastase induced increase in vascular perfusion, as well as the number of rolling adherent leukocytes, and also significantly attenuated hindpaw allodynia.
体外研究：
GB83 (10 μM) blocks the effect of MET-1 (microbial ecosystem therapeutic-1) supernatant on nodose ganglion (NG) neurons.
GB83 is a potent PAR2 antagonist. GB83 reverses neutrophil elastase‐induced synovitis and pain. GB83 blocks the effect of MET-1 supernatant on NG neurons.
体内研究：
GB83 (5 μg; i.p.) reverses neutrophil elastase‐induced synovitis and pain in PAR2 KO mice.Animal Model:8-14 weeks, 20-30 g male C57Bl/6 mice (PAR2 KO mice)
Dosage:5 μg
Administration:I.p.; 3 times at 10?min before and 110 and 230?min after neutrophil elastase administered
Result:Significantly blocked the neutrophil elastase induced increase in vascular perfusion, as well as the number of rolling adherent leukocytes, and also significantly attenuated hindpaw allodynia.
体外研究：
GB83 (10 μM) blocks the effect of MET-1 (microbial ecosystem therapeutic-1) supernatant on nodose ganglion (NG) neurons.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备