产品
编 号：F625470
分子式：C15H8O5
分子量：268.22
分子式：C15H8O5
分子量：268.22
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 1259330-61-4
产品详情
生物活性：
Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities.
体内研究：
Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice.Animal Model:5-6-week-old male C57Bl/6 mice (body weight 18-20 g)
Dosage:100 μg/mouse
Administration:I.p.
Result:Significantly lower TNFα and IL-1β expression levels in LPS-induced sepsis mouse model.
体外研究：
Sparstolonin B (1-20 μM; 2-4 days) inhibits cell growth and viability of neuroblastoma cells.Sparstolonin B inhibits TLR ligand-induced cytokine expression in mouse macrophages. Sparstolonin B inhibits MyD88 recruitment to TLR4 and TLR2.Sparstolonin B generates reactive oxygen species (ROS) in neuroblastoma cells. Sparstolonin B reduces expression of N-myc in neuroblastoma cells.
Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities.
体内研究：
Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice.Animal Model:5-6-week-old male C57Bl/6 mice (body weight 18-20 g)
Dosage:100 μg/mouse
Administration:I.p.
Result:Significantly lower TNFα and IL-1β expression levels in LPS-induced sepsis mouse model.
体外研究：
Sparstolonin B (1-20 μM; 2-4 days) inhibits cell growth and viability of neuroblastoma cells.Sparstolonin B inhibits TLR ligand-induced cytokine expression in mouse macrophages. Sparstolonin B inhibits MyD88 recruitment to TLR4 and TLR2.Sparstolonin B generates reactive oxygen species (ROS) in neuroblastoma cells. Sparstolonin B reduces expression of N-myc in neuroblastoma cells.
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