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编 号：F624682
分子式：C32H28NNaO5
分子量：529.56
分子式：C32H28NNaO5
分子量：529.56
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CAS No: 1316755-17-5
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生物活性：
Olodanrigan (EMA401) sodium is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. Olodanrigan sodium is under development as a neuropathic pain therapeutic agent. Olodanrigan sodium analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.
体内研究：
EMA401 sodium（10mg/kg；口服）导致慢性压迫性损伤 (CCI) 后第 14 天大鼠的 θ 功率显着减弱和缩爪潜伏期 (PWL) 增加。
Olodanrigan (EMA401) sodium is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. Olodanrigan sodium is under development as a neuropathic pain therapeutic agent. Olodanrigan sodium analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.
体内研究：
EMA401 sodium（10mg/kg；口服）导致慢性压迫性损伤 (CCI) 后第 14 天大鼠的 θ 功率显着减弱和缩爪潜伏期 (PWL) 增加。
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