产品
编 号：F624613
分子式：C9H12ClFN6O4
分子量：322.68
分子式：C9H12ClFN6O4
分子量：322.68
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 1333126-31-0
产品详情
生物活性：
Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains. Azvudine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
体外研究：
Azvudine (RO-0622) hydrochloride 对野生型 HIV-1IIIB 和 HIV-1RF 具有强抑制作用，EC50 范围为 30-110 pM。Azvudine hydrochloride 对 HIV-1KM018、HIV-1TC-1 和 HIV-1WAN T69N 的 EC50 值 分别为 6.92、0.34 和 0.45 nM。Azvudine hydrochloride 对 NRTIs 耐药株 HIV-174V、PIs 耐药株 HIV-1L10R/M46I/L63P/V82T/I84V 和 HIV-1RF V82F/184V 和 FIs 耐药株 pNL4-3gp41 (36G) V38A/N42T 的 EC50 值分别为 0.11、0.14、0.37 和 0.36 nM。
Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains. Azvudine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
体外研究：
Azvudine (RO-0622) hydrochloride 对野生型 HIV-1IIIB 和 HIV-1RF 具有强抑制作用，EC50 范围为 30-110 pM。Azvudine hydrochloride 对 HIV-1KM018、HIV-1TC-1 和 HIV-1WAN T69N 的 EC50 值 分别为 6.92、0.34 和 0.45 nM。Azvudine hydrochloride 对 NRTIs 耐药株 HIV-174V、PIs 耐药株 HIV-1L10R/M46I/L63P/V82T/I84V 和 HIV-1RF V82F/184V 和 FIs 耐药株 pNL4-3gp41 (36G) V38A/N42T 的 EC50 值分别为 0.11、0.14、0.37 和 0.36 nM。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备