产品
编 号：F624582
分子式：C15H18ClNO3
分子量：295.76
分子式：C15H18ClNO3
分子量：295.76
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
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询价
结构图
CAS No: 1335282-05-7
产品详情
生物活性：
CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia.
体内研究：
CN128 hydrochloride (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat.The iron removal efficacies of CN128 displays a dose-dependent behavior.CN128 hydrochloride lacks genetic toxicity.CN128 hydrochloride (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg.CN128 hydrochloride is well-tolerated, with no mortality being observed at the higher dose levels in rats.Animal Model:Male SD rats (300 g)
Dosage:450 μmol/kg
Administration:Oral gavage, 1 hour after 59Fe-ferritin injection
Result:Exhibited good iron scavenging activity.
Animal Model:Sprague-Dawley rats (200~250 g)
Dosage:75 μmol/kg (Pharmacokinetic Analysis)
Administration:Oral administration
Result:AUC values= 16.38 mg/L?h, Cmax=8.671 mg/L.
体外研究：
CN128 hydrochloride possesses a high selectivity for iron(III) over others metals.
CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia.
体内研究：
CN128 hydrochloride (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat.The iron removal efficacies of CN128 displays a dose-dependent behavior.CN128 hydrochloride lacks genetic toxicity.CN128 hydrochloride (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg.CN128 hydrochloride is well-tolerated, with no mortality being observed at the higher dose levels in rats.Animal Model:Male SD rats (300 g)
Dosage:450 μmol/kg
Administration:Oral gavage, 1 hour after 59Fe-ferritin injection
Result:Exhibited good iron scavenging activity.
Animal Model:Sprague-Dawley rats (200~250 g)
Dosage:75 μmol/kg (Pharmacokinetic Analysis)
Administration:Oral administration
Result:AUC values= 16.38 mg/L?h, Cmax=8.671 mg/L.
体外研究：
CN128 hydrochloride possesses a high selectivity for iron(III) over others metals.
产品资料
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