产品
编 号：F624567
分子式：C18H23F3N2O5
分子量：404.38
分子式：C18H23F3N2O5
分子量：404.38
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1336913-03-1
产品详情
生物活性：
PSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively.
体内研究：
PSEM 89S strongly reduces photostimulation-evoked feeding in mice expressing PSAML141F,Y115F- glycine receptor (GlyR) (30 mg/kg) but not in mice expressing only channelrhodopsin-2 (ChR2) (50 mg/kg).PSEM 89S (30 mg/kg) shows good brain penetrance in mice after minimally invasive intraperitoneal administration.Animal Model:Male Agrp-cre mice (3-6 weeks)
Dosage:30 mg/kg
Administration:I.p. administration
Result:Almost completely suppressed fos (a marker of neuron activation) in ChR2-expressing neurons.
Animal Model:C57BL/6 mice
Dosage:30 mg/kg (Pharmacokinetic Analysis)
Administration:I.p. administration
Result:Rised rapidly in serum and brain, and was mostly cleared from both compartments in 1 h.
体外研究：
PSEM 89S (10 or 30μM) activates layer 2/3 cortical neurons expressing (Pharmacologically Selective Actuator Module) PSAML141F,Y115F-5HT3 high conductance (HC).PSEM 89S (10 μM) reversibly silenced transfected neurons by reducing cellular input resistance.
PSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively.
体内研究：
PSEM 89S strongly reduces photostimulation-evoked feeding in mice expressing PSAML141F,Y115F- glycine receptor (GlyR) (30 mg/kg) but not in mice expressing only channelrhodopsin-2 (ChR2) (50 mg/kg).PSEM 89S (30 mg/kg) shows good brain penetrance in mice after minimally invasive intraperitoneal administration.Animal Model:Male Agrp-cre mice (3-6 weeks)
Dosage:30 mg/kg
Administration:I.p. administration
Result:Almost completely suppressed fos (a marker of neuron activation) in ChR2-expressing neurons.
Animal Model:C57BL/6 mice
Dosage:30 mg/kg (Pharmacokinetic Analysis)
Administration:I.p. administration
Result:Rised rapidly in serum and brain, and was mostly cleared from both compartments in 1 h.
体外研究：
PSEM 89S (10 or 30μM) activates layer 2/3 cortical neurons expressing (Pharmacologically Selective Actuator Module) PSAML141F,Y115F-5HT3 high conductance (HC).PSEM 89S (10 μM) reversibly silenced transfected neurons by reducing cellular input resistance.
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