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编 号：F623901
分子式：C40H54N8O6S
分子量：774.97
分子式：C40H54N8O6S
分子量：774.97
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CAS No: 1383551-17-4
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生物活性：
SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect.
体内研究：
SRT3657 (30 mg/kg; i.g.; daily; for 6 weeks) activates SIRT1 in CK-p25 mice.SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments.SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR).Animal Model:Adult double-transgenic CK-p25 mice (3-month-old)
Dosage:30 mg/kg
Administration:Oral gavage, daily, for 6 weeks
Result:Significantly upregulated the activity of SIRT1 in hippocampal extracts of CK-p25 animals.
SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect.
体内研究：
SRT3657 (30 mg/kg; i.g.; daily; for 6 weeks) activates SIRT1 in CK-p25 mice.SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments.SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR).Animal Model:Adult double-transgenic CK-p25 mice (3-month-old)
Dosage:30 mg/kg
Administration:Oral gavage, daily, for 6 weeks
Result:Significantly upregulated the activity of SIRT1 in hippocampal extracts of CK-p25 animals.
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