产品
编 号：F623776
分子式：C22H22O4
分子量：350.41
分子式：C22H22O4
分子量：350.41
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1393922-01-4
产品详情
生物活性：
Millepachine is a bioactive natural chalcone from Chinese herbal medicine Millettia pachycarpa Benth, exhibits strong antitumor effects against numerous human cancer cells both in vitro and in vivo.
体内研究：
Millepachine (20 mg/kg; i.v. every two days for 14 day) inhibits tumor growth in mice.Millepachine (20 mg/kg; i.v. every two days for 14 day) does not induce acquired drug resistance in an excised A2780S xenograft model.Animal Model:Female BALB/c nude mice (6 weeks) are injected A2780S or A2780CP cells
Dosage:20 mg/kg
Administration:I.v. every two days for 2-14 days
Result:Reduced tumor volume and tumor weight with the inhibitory rate of 73.21% and 65.58% in A2780S (after seven times injection) and A2780CP (after six times injection) xenograft model, respectively.With low toxicity in vivo.
体外研究：
Millepachine (1.25-20 μM; 48 h) remarkably inhibits the proliferation of cisplatin-resistant A2780CP cells.Millepachine (2-8 μM; 24 or 48 h) induces G2/M arrest and apoptosis cisplatin-sensitive A2780S and cisplatin-resistant A2780CP cells.Millepachine (2-8 μM; 24 h) decreases topoisomerase II levels in A2780S and A2780CP cells.Millepachine (2-8 μM; 24 h) inhibits ATP-binding cassette transporter activity in A2780CP cells.
Millepachine is a bioactive natural chalcone from Chinese herbal medicine Millettia pachycarpa Benth, exhibits strong antitumor effects against numerous human cancer cells both in vitro and in vivo.
体内研究：
Millepachine (20 mg/kg; i.v. every two days for 14 day) inhibits tumor growth in mice.Millepachine (20 mg/kg; i.v. every two days for 14 day) does not induce acquired drug resistance in an excised A2780S xenograft model.Animal Model:Female BALB/c nude mice (6 weeks) are injected A2780S or A2780CP cells
Dosage:20 mg/kg
Administration:I.v. every two days for 2-14 days
Result:Reduced tumor volume and tumor weight with the inhibitory rate of 73.21% and 65.58% in A2780S (after seven times injection) and A2780CP (after six times injection) xenograft model, respectively.With low toxicity in vivo.
体外研究：
Millepachine (1.25-20 μM; 48 h) remarkably inhibits the proliferation of cisplatin-resistant A2780CP cells.Millepachine (2-8 μM; 24 or 48 h) induces G2/M arrest and apoptosis cisplatin-sensitive A2780S and cisplatin-resistant A2780CP cells.Millepachine (2-8 μM; 24 h) decreases topoisomerase II levels in A2780S and A2780CP cells.Millepachine (2-8 μM; 24 h) inhibits ATP-binding cassette transporter activity in A2780CP cells.
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