产品
编 号：F623708
分子式：C15H14N4O
分子量：266.3
分子式：C15H14N4O
分子量：266.3
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 1401731-54-1
产品详情
生物活性：
MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation.
体外研究：
MRT00033659 (5-40 μM; 48 hours) is sufficient to significantly reduce cell number of 5 μM. MRT00033659 (1-80 μM; 48 hours) induces substantial cell death from 5 μM. MRT00033659 (0.2-80 μM; 48 hours) induces a robust and sustained stabilisation of p53, MDM2 and p21 proteins, as well as E2F-1 destabilisation from 0.2 μM to 5 μM. MRT00033659 does not inhibit p38α MAPK.
MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation.
体外研究：
MRT00033659 (5-40 μM; 48 hours) is sufficient to significantly reduce cell number of 5 μM. MRT00033659 (1-80 μM; 48 hours) induces substantial cell death from 5 μM. MRT00033659 (0.2-80 μM; 48 hours) induces a robust and sustained stabilisation of p53, MDM2 and p21 proteins, as well as E2F-1 destabilisation from 0.2 μM to 5 μM. MRT00033659 does not inhibit p38α MAPK.
产品资料
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