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编 号:F623436
分子式:C15H19N5O3
分子量:317.34
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CAS No: 1418747-15-5
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AZ3976 is a potent plasminogen activator inhibitor type 1 (PAI-1) inhibitor with an IC50?value of 26 μM?in an enzymatic chromogenic assay. AZ3976 is active with an IC50?of 16 μM in a plasma clot lysis assay.?AZ3976 does not bind to active PAI-1 but bound reversibly to latent PAI-1. AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1. AZ3976 displays profibrinolytic activities in a human plasma clot lysis assay.