产品
编 号：F623221
分子式：C15H11N3O4S
分子量：329.33
分子式：C15H11N3O4S
分子量：329.33
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CAS No: 1436382-03-4
产品详情
生物活性：
LY5 is a STAT3 inhibitor with an IC50 value of 0.5 μM. LY5 induces apoptosis and inhibits STAT3 phosphorylation. LY5 shows antitumor activity in vivo, it can be used for the research of cancer.
体内研究：
LY5 (5 mg/kg; i.p. once daily for 21 days) inhibits breast tumor growth in vivo.Animal Model:Nude mice with MDA-MB-231 cancer cells injection
Dosage:5 mg/kg
Administration:Intraperitoneal injection; 5 mg/kg; once daily; for 21 days
Result:Suppressed tumor growth and significantly reduced the tumor sizes.
体外研究：
LY5 shows inhibition effects to U2OS, RH30 and RD2 cancer cells with IC50 values of 0.52, 0.55 and 1.39 μM, respectively.LY5 (0.25-1 μM; 16 h) induces apoptosis and inhibits STAT3 phosphorylation in human sarcoma cancer cells.LY5 (0.25-1 μM; 5 h) inhibits STAT3 phosphorylation induced by IL-6.
LY5 is a STAT3 inhibitor with an IC50 value of 0.5 μM. LY5 induces apoptosis and inhibits STAT3 phosphorylation. LY5 shows antitumor activity in vivo, it can be used for the research of cancer.
体内研究：
LY5 (5 mg/kg; i.p. once daily for 21 days) inhibits breast tumor growth in vivo.Animal Model:Nude mice with MDA-MB-231 cancer cells injection
Dosage:5 mg/kg
Administration:Intraperitoneal injection; 5 mg/kg; once daily; for 21 days
Result:Suppressed tumor growth and significantly reduced the tumor sizes.
体外研究：
LY5 shows inhibition effects to U2OS, RH30 and RD2 cancer cells with IC50 values of 0.52, 0.55 and 1.39 μM, respectively.LY5 (0.25-1 μM; 16 h) induces apoptosis and inhibits STAT3 phosphorylation in human sarcoma cancer cells.LY5 (0.25-1 μM; 5 h) inhibits STAT3 phosphorylation induced by IL-6.
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