产品
编 号：F623122
分子式：C43H43ClN4O6
分子量：747.28
分子式：C43H43ClN4O6
分子量：747.28
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 1448525-91-4
产品详情
生物活性：
S55746 hydrochloride (BCL201 hydrochloride) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 hydrochloride (BCL201 hydrochloride) has antitumor activity with low toxicity.
体内研究：
S55746 is a highly efficacious and well-tolerated (even at doses up to 300 mg/kg) orally active BCL-2 inhibitor . S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth in RS4;11 and Toledo models time- and dose-dependently.Animal Model:Female SCID/beige mice implanted subcutaneously with 3×106 Toledo or RS4;11.
Dosage:20, 50, 100 mg/kg.
Administration:Oral gavage daily for 7 consecutive days.
Result:Induced significant anti-tumor activity time- and dose-dependently.
Animal Model:SCID/beige female mice with RS4;11 tumor xenografts.
Dosage:25 and 100 mg/kg.
Administration:Single oral gavage treatment.
Result:Did not induce platelet loss in vivo at 25 and 100 mg/kg.
体外研究：
S55746 (0-1 μM) potently and selectively induces cell death.S55746 selectively induces apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner.
S55746 hydrochloride (BCL201 hydrochloride) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 hydrochloride (BCL201 hydrochloride) has antitumor activity with low toxicity.
体内研究：
S55746 is a highly efficacious and well-tolerated (even at doses up to 300 mg/kg) orally active BCL-2 inhibitor . S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth in RS4;11 and Toledo models time- and dose-dependently.Animal Model:Female SCID/beige mice implanted subcutaneously with 3×106 Toledo or RS4;11.
Dosage:20, 50, 100 mg/kg.
Administration:Oral gavage daily for 7 consecutive days.
Result:Induced significant anti-tumor activity time- and dose-dependently.
Animal Model:SCID/beige female mice with RS4;11 tumor xenografts.
Dosage:25 and 100 mg/kg.
Administration:Single oral gavage treatment.
Result:Did not induce platelet loss in vivo at 25 and 100 mg/kg.
体外研究：
S55746 (0-1 μM) potently and selectively induces cell death.S55746 selectively induces apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner.
产品资料
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