产品
编 号：F623121
分子式：C43H42N4O6
分子量：710.82
分子式：C43H42N4O6
分子量：710.82
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1448584-12-0
产品详情
生物活性：
S55746 (BCL201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BCL201) has antitumor activity with low toxicity.
体内研究：
S55746 是一种高效且耐受性良好 (即使剂量高达 300 mg/kg) 的口服活性 BCL-2 抑制剂。 S55746 (20-100 mg/kg，po) 时间和剂量依赖性抑制 RS4；11 和 Toledo 模型中的异种移植物生长。Animal Model:Female SCID/beige mice implanted subcutaneously with 3×106 Toledo or RS4;11.
Dosage:20, 50, 100 mg/kg.
Administration:Oral gavage daily for 7 consecutive days.
Result:Induced significant anti-tumor activity time- and dose-dependently.
Animal Model:SCID/beige female mice with RS4;11 tumor xenografts.
Dosage:25 and 100 mg/kg.
Administration:Single oral gavage treatment.
Result:Did not induce platelet loss in vivo at 25 and 100 mg/kg.
体外研究：
S55746 (0-1 μM) 有效并选择性地诱导细胞死亡。 S55746 以 BAX/BAK 依赖性方式通过 BCL-2 抑制选择性诱导细胞凋亡。
S55746 (BCL201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BCL201) has antitumor activity with low toxicity.
体内研究：
S55746 是一种高效且耐受性良好 (即使剂量高达 300 mg/kg) 的口服活性 BCL-2 抑制剂。 S55746 (20-100 mg/kg，po) 时间和剂量依赖性抑制 RS4；11 和 Toledo 模型中的异种移植物生长。Animal Model:Female SCID/beige mice implanted subcutaneously with 3×106 Toledo or RS4;11.
Dosage:20, 50, 100 mg/kg.
Administration:Oral gavage daily for 7 consecutive days.
Result:Induced significant anti-tumor activity time- and dose-dependently.
Animal Model:SCID/beige female mice with RS4;11 tumor xenografts.
Dosage:25 and 100 mg/kg.
Administration:Single oral gavage treatment.
Result:Did not induce platelet loss in vivo at 25 and 100 mg/kg.
体外研究：
S55746 (0-1 μM) 有效并选择性地诱导细胞死亡。 S55746 以 BAX/BAK 依赖性方式通过 BCL-2 抑制选择性诱导细胞凋亡。
产品资料
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