产品
编 号：F623091
分子式：C20H21ClFN5O3S
分子量：465.93
分子式：C20H21ClFN5O3S
分子量：465.93
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1450595-86-4
产品详情
生物活性：
DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC50s of 22.8 and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects.
体内研究：
DS-1971a exhibits a favorable toxicological profile.DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice.Animal Model:Male Slc:ddY mice (PSL model)
Dosage:0.1, 0.3, and 1 mg/kg
Administration:P.o.
Result:A significant dose-dependent suppression of thermal hyperalgesiain 0.3 and 1 mg/kg administered groups. The ED50 of DS-1971a at the peak efficacy was 0.32 mg/kg.
DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC50s of 22.8 and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects.
体内研究：
DS-1971a exhibits a favorable toxicological profile.DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice.Animal Model:Male Slc:ddY mice (PSL model)
Dosage:0.1, 0.3, and 1 mg/kg
Administration:P.o.
Result:A significant dose-dependent suppression of thermal hyperalgesiain 0.3 and 1 mg/kg administered groups. The ED50 of DS-1971a at the peak efficacy was 0.32 mg/kg.
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