产品
编 号：F623017
分子式：C20H29N3O11
分子量：487.46
分子式：C20H29N3O11
分子量：487.46
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
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询价
结构图
CAS No: 1470302-79-4
产品详情
生物活性：
ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3.
体内研究：
ZYZ-488 (33.9-67.8 mg/kg; intramuscularly; for 3 days) protected against myocardial apoptosis.Animal Model:Male C57BL/6 mice (8-10 weeks old)
Dosage:myocardial infarction?+?ZYZ-488 (33.9?mg/kg); myocardial infraction?+?ZYZ-488 (67.8?mg/kg);
Administration:Intramuscularly; for 3 days
Result:Inhibited Apaf-1-mediated activation of procaspase-9 and procaspase-3.
体外研究：
ZYZ-488 decreases apoptosis in hypoxic H9c2 cells. ZYZ-488 inhibits hypoxia induced Apaf-1-mediated activation of procaspase-9 and procaspase-3. ZYZ-488 decreases myocardial enzyme release, inhibits cardiomyocyte apoptosis, and suppresses the activation of the downstream cascade of caspases.
ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3.
体内研究：
ZYZ-488 (33.9-67.8 mg/kg; intramuscularly; for 3 days) protected against myocardial apoptosis.Animal Model:Male C57BL/6 mice (8-10 weeks old)
Dosage:myocardial infarction?+?ZYZ-488 (33.9?mg/kg); myocardial infraction?+?ZYZ-488 (67.8?mg/kg);
Administration:Intramuscularly; for 3 days
Result:Inhibited Apaf-1-mediated activation of procaspase-9 and procaspase-3.
体外研究：
ZYZ-488 decreases apoptosis in hypoxic H9c2 cells. ZYZ-488 inhibits hypoxia induced Apaf-1-mediated activation of procaspase-9 and procaspase-3. ZYZ-488 decreases myocardial enzyme release, inhibits cardiomyocyte apoptosis, and suppresses the activation of the downstream cascade of caspases.
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