产品
编 号：F622769
分子式：C27H32N6O2
分子量：472.58
分子式：C27H32N6O2
分子量：472.58
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 1550371-22-6
产品详情
生物活性：
BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 free base blocks MM-induced NET formation and delays progression of MM in a syngeneic mouse model.
体内研究：
BMS-P5 (50 mg/kg，灌胃) 显著提高荷瘤小鼠的存活率。BMS-P5 (50 mg/kg，灌胃) 可能减弱肿瘤微环境中存在促致瘤蛋白，从而延缓肿瘤进展。Animal Model:Syngeneic mouse model of MM.
Dosage:50 mg/kg.
Administration:Oral gavage, twice a day beginning on day 3 after tumor cell injection.
Result:Significantly delayed development of symptoms and significantly prolonged survival of MM-bearing mice.
体外研究：
BMS-P5 可阻断钙离子载体诱导的组蛋白 H3 瓜氨酸化。BMS-P5 还能够抑制由原代 MM 细胞诱导的 NETs 形成MM。
BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 free base blocks MM-induced NET formation and delays progression of MM in a syngeneic mouse model.
体内研究：
BMS-P5 (50 mg/kg，灌胃) 显著提高荷瘤小鼠的存活率。BMS-P5 (50 mg/kg，灌胃) 可能减弱肿瘤微环境中存在促致瘤蛋白，从而延缓肿瘤进展。Animal Model:Syngeneic mouse model of MM.
Dosage:50 mg/kg.
Administration:Oral gavage, twice a day beginning on day 3 after tumor cell injection.
Result:Significantly delayed development of symptoms and significantly prolonged survival of MM-bearing mice.
体外研究：
BMS-P5 可阻断钙离子载体诱导的组蛋白 H3 瓜氨酸化。BMS-P5 还能够抑制由原代 MM 细胞诱导的 NETs 形成MM。
产品资料
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